currently have five published scientific manuscripts specific to our retinal metabolic analysis (RMA™) technique. The most recent manuscript demonstrates in vitro and ex vivo that increases in flavoprotein fluorescence correlate with an established in vitro measure of mitochondrial dysfunction and that increases in flavoprotein fluorescence occur before cell death. This substantiates our claim that we are detecting retinal metabolic dysfunction using our clinical instrument. Our four published clinical studies show that RMA™ detects increased metabolic dysfunction in patients with diabetes, macular degeneration, central serous retinopathy, and optic nerve disease. |
Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression.
Exp Eye Res 2011 July 15. [Epub ahead of print].
Rapid, non-invasive detection of diabetes-induced retinal metabolic stress.
Arch Ophthalmol 2008;126:934-8.
Retinal flavoprotein autofluorescence as a measure of
Trans Am Ophthalmol Soc 2008;106:215-24.
Detection of retinal metabolic stress resulting from central serous retinopathy.
Flavoprotein autofluorescence detection of
early ocular dysfunction.
Arch Ophthalmol 2008;126:259-60.